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Clinical evidence pertaining to migraines, oxidative stress, and neurogenic inflammation, along with experimental evidence of topiramates antioxidative and anti-inflammatory effects, provide strong hypothetical support for the idea that topiramate may treat migraines by blocking oxidative stress and neurogenic inflammation pathways

Proc Natl Acad Sci 97(15):84848489 Haviv F et al (2005) Thrombospondin-1 mimetic peptide inhibitors of angiogenesis and tumor growth: design, synthesis, and optimization of pharmacokinetics and biological activities

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