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Cholesterol overload in neuronal cells promotes pyroptosis by enhancing A-induced mitochondrial oxidative stress Previous studies have linked the pathway of inflammasome signaling evoked by A in neurons to pyroptosis [48, 49], a programmed cell death that features cell swelling and plasma membrane disruption

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doi: 10.3389/fmed.2025.1713327 Received 25 September 2025 Revised 01 December 2025 Accepted 08 December 2025 Published 02 January 2026 Volume 12 - 2025 Edited by Jianjing Lin, Peking University, China Reviewed by Wei Wei, Harbin Medical University, China Jian Zhang, Guizhou University of Traditional Chinese Medicine, China Updates Copyright 2026 Zhu, Wu, Peng, He, Hu and Xiao

TB-500 acts via actin sequestration and cell migration and shows robust effects in dermal, muscular, and cardiac models

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