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Using a long-term HFD-fed mouse model of NAFLD, we demonstrated in this study that NAFLD development occurs concomitantly with dysregulated hepatic glutathione homeostasis characterized by decreased GSH and increased GSSG, and increased TNF protein levels in both the circulation and the liver

Psychiatry 86 , 216221 (2015)

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( c ) Cyclin E1 and IDH1 immunoblot in cells transduced with shRNAs targeting IDH1 (shIDH1)