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As immune cells age, particularly T cells, mitochondrial efficiency declines, leading to reduced ATP production, increased ROS generation, and impaired mitophagy

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Howard J, Hemmaway CJ, Telfer P et al (2019) A phase 1/2 ascending dose study and open-label extension study of voxelotor in patients with sickle cell disease

Figure 8 Discussion Circadian variation in asthma severity has been recognized for decades, yet the hormonal mechanisms underlying this phenomenon remain incompletely understood