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Maintenance of NAD + levels is vital for proficient neuronal function

Either overexpression of NAMPT or supplementation of NMN can increase the mitochondria and total cellular NAD + levels of ALS astrocytes, thereby enhancing the ability to resist oxidative stress and restoring the toxicity of astrocytes to motor neurons

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This distinction helps explain why it progressed into formal obesity trials, whereas the raw fragment itself did not

The abnormal function of these neurotransmitters is associated with several neurological diseases, such as ASD [146, 147]