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doi: 10.1097/00075197-200501000-00011 100 LeeHWOsisGHandlogtenMEGuoHVerlanderJWWeinerID

Increased mitoses, cytological alterations, and nuclear alterations may be present

Although the contribution of dietary methionine excess (which increases folate, vitamin B 6 , and vitamin B 12 requirements) has not been clinically assessed, folate deficiency (associated or not with the thermolabile MTHFR mutation) and vitamin B 6 deficiency (associated or not with heterozygosity for CBS defects) could largely account for this increased risk of hyperhomocysteinemia-related cardiovascular disease

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