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Luciferase reporter assay Luciferase reporter assays were performed as described previously 82,123

This hepatic lipid clearance results from glucagon receptor activation, which increases hepatic fatty acid oxidation and VLDL secretion, mechanisms that cagrilintides amylin-only agonism doesnt replicate

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Although it is not a primary benefit

At the time of these studies, the roles of reactive oxygen species (ROS) in cells were poorly characterised and information on subcellular compartmentation was at best fragmentary