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Shbeeb et al ., J Rheumatol , 1996

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Targeting modules introduce cellular or tissue selectivity through ligandreceptor recognition or the use of cell-penetrating peptides [53, 54]

CONCLUDING REMARKS AND OUTLOOK In this article, we have reviewed the concept and clinical potential of ADCs and various conjugation/linker strategies for constructing this new class of molecules (Table 1)

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activation of matrix metalloproteinases (MMP-2) for remodeling