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Lactate at the crossroads of metabolism, inflammation, and autoimmunity

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It appears to assist normal metabolic function and thus may reverse the damage caused by oxygen deprivation, protecting tissues until blood flow is restored

Dan and Baldwin [81] revealed that insulin and TNF activated mTOR through both the AKT/mTOR and the AKT/IKK/mTOR pathways, whereas TNF also activated mTOR via the IKK-mediated signaling independently of the PI3K/AKT pathway in several cell types