The increasing global cancer burden, with an estimated 20 million new cases and 9.7 million deaths globally in 2022 with projections indicating a 77% increase in incidence by 2050 and the limitations of current treatments, which are exemplified by the fact that despite advancements in cancer detection, treatment and supportive care, survival outcomes remain suboptimal for many patients, together highlight an unmet need for novel therapeutic agents that are both effective and safe (1)
Tyrosine hydroxylase is the critical enzyme in the synthesis of epinephrine, norepinephrine and dopamine, and tryptophan hydroxylase is the essential enzyme in the synthesis of serotonin
One of the major functions of the liver is its breakdown of fat
Front Physiol (2018) 9:477
This has led to the approval of tesamorelin for therapy in abnormal fat distribution called lipodystrophy which often occurs in HIV-infected individuals
Cerebral blood flow is reduced in ME/CFS during head-up tilt testing even in the absence of hypotension or tachycardia: A quantitative, controlled study using Doppler echography
