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That triple mechanism is what produced the headline-grabbing results from the Phase 2 NEJM trial, where the 12 mg dose group achieved an average 24.2% body weight reduction over 48 weeks

INDICATIONS AND DIAGNOSIS Patients with arthritis of the tarsal tunnel may complain of a burning sensation, pain, and paresthesias over the distribution of the posterior tibial nerve and its branches that worsen with weight bearing

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Curr Pharm Des 20(7):11261135 Sikiric P, Seiwerth S, Rucman R et al (2016) Brain-gut axis and pentadecapeptide BPC 157