A modified FOXO4-p53 interfering peptide causes p53 nuclear exclusion, which can: Selectively induce apoptosis in senescent cells in vitro and in vivo Neutralize phenotypical and liver chemotoxicity by Doxorubicin Restore fitness, hair density and renal function in fast and naturally aged mice Acknowledgments We thank Felicity Chandler for assistance with IHC experiments, Anne Drabbe and David Brouwer for assistance with in vivo experiments, Yanto Ridwan for assistance with CT and IVIS imaging, Yvette van Loon for genotyping of the mice, Martin Viertler for initial NMR experiments, Boudewijn Burgering for fruitful discussions and Petra de Keizer-Burger for critical reading of the manuscript
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The organ damages following hyperglycemia/ROS stress can be hindered by initiating good glycemic control very early, but is not easily reversed if poorly handled over a longer time period 19
Morris, youll create an individualized treatment plan based on a collaboration between compassionate, evidence-based strategies and your own goals and insight
Tests include grip strength, continuous glucose monitoring, at-home sleep apnea tests, a full-body MRI, and more
