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This reduced activity, combined with a potentially slower metabolism that can occur with persistent nutrient deficiencies, could indirectly contribute to weight gain over time

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The real reasons to cycle are different and better: the long-term human safety picture is a blank, it meaningfully shifts systemic methylation the literature admits it hasnt mapped, and sustained inhibition may invite compensatory pathways

Obese individuals often exhibit both elevated NNMT in adipose tissue and impaired muscle regenerative capacity a connection that NNMTs dual tissue effects could help explain