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Retatrutide additionally shows a dose-dependent increase in heart rate, attributed to its glucagon-receptor activity, and indirect network meta-analyses flag the highest adverse-event burden among the modern agents for the most potent drugs

Longer exposure appeared to be detrimental or toxic to the neurons

In the phase I/II clinical trials of ADI-PEG20 on melanoma, it was well tolerance without serious adverse reactions [140, 141]

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