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Alm da idade, outros fatores impactam os nveis de glutationa e provocam deficincias, inclusive: Exposio ambiental poluio, aos metais pesados, fumaa e radiao UV Dieta inadequada, uso excessivo de lcool e sedentarismo Condies genticas Uso crnico de mltiplos medicamentos Um nmero cada vez maior de estudos demonstra que a deficincia de glutationa est associada a diversas doenas e perda de funo com a idade

Hoogeveen EK, Kostense PJ, Jakobs C, Dekker JM, Nijpels G, Heine RJ, Bouter LM, and Stehouwer CD (2000)

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However, our findings revealed that analogs with a single deletion of His or Trp were not highly effective as antagonists