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In: Global cancer observatory: cancer today (version 11)

In ameliorating IR, it activates the PI3K/AKT signaling cascade, upregulating the mRNA and protein expression of IRS-1 and GLUT4 while downregulating phosphorylated IRS-1 (p-IRS-1 at Ser307), thereby augmenting cellular glucose uptake (151)

It is theorized that this process could involve the activation of the PI3K-Akt and JAK2-STAT5 pathways (pathways with essential roles in cell growth, survival, and metabolism), along with a reduction in NF-B-mediated gene transcription (proinflammatory pathways that can lead to cell damage and death)

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Protein production by auto-induction in high-density shaking cultures