After 4 weeks of oral administration of 5amino1mq tablets (510 mg/kg) to aged mice (1820 months old), muscle mass was significantly increased, grip strength was enhanced by approximately 40% compared with the control group, and muscle endurance and exercise capacity were also notably improved.Further studies revealed that 5amino1mq inhibits excessive NNMT activation in muscle tissue, restores NAD levels, activates the SIRT1 pathway, reduces muscle protein degradation, and promotes muscle protein synthesis, thereby maintaining muscle mass
Data availability The dataset supporting the conclusions of this article is available in the SRA repository [ information is available in the Additional files 1 to 4
To clarify their relative importance, we examined Cyp7a1 induction in response to oral glucose loading in Kir6.2 deficient mice ( Kir6.2 / mice), which lack glucose-stimulated insulin secretion 13
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