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These effects include energy metabolism, mitochondrial homeostasis, epigenetic regulation, endocrine regulation, inflammation and immune homeostasis, signal transduction, and neuromodulation (Fig

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However, this increase in fat oxidation did not lead to measurable changes in body composition in the study

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However, the aforementioned analysis does provide a rationale for individuals who have tried melatonin (taken shortly before bedtime) without success to try again with dosing about three hours before bedtime