The HGF/c-Met pathway is one of the brain's core growth and repair systems
Key Innovation: The addition of a C18 fatty diacid side chain extends its half-life to approximately 7 days, enabling once-weekly dosing similar to modern GLP-1 receptor agonists
It also induces psychiatric symptoms, such as euphoria, hypervigilance, interpersonal sensitivity, impaired judgment, paranoid delusions, hallucinations, and bizarre behaviors (Roncero et al., 2013)
10.1016/S0016-5085(98)70636-5 35
These changes can contribute to a buildup of plaque in your arteries, increasing the risk of heart attack and stroke
Intervention studies employing dopaminergic neuron-targeted PGC-1 overexpression via adeno-associated viral vectors reveal enhanced redox homeostasis in striatal neurons and marked attenuation of programmed dopaminergic cell death, establishing this transcriptional coactivators neuroprotective capacity in PD pathophysiology (Wang et al., 2019c)