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A randomized, placebo-controlled trial in 559 elderly individuals with low serum levels of folate and vitamin B 12 and at increased risk of fracture evaluated the combined supplementation of very high doses of folic acid (5 mg/day) and vitamin B 12 (1.5 mg/day)
However, absorption challenges and individual variability in effectiveness have led many Richmond healthcare providers to recommend vitamin B12 injections as a more reliable delivery method
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Routine rechecking of serum B12 levels is not generally recommended for patients on regular injections as levels will be artificially high