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A titration is used to determine the total acidity in the grapes, which acts as a proxy for determining how tart the resulting wine will be

If laboratory testing shows low or low-normal B12 levels despite weekly injections, additional supplementation is appropriate and beneficial

Surveillance should be offered to patients with reasonable life expectancy so that therapy for progression (if detected) would be tolerated and would benefit the patient

Research-grade preparations should have an HPLC purity of at least 99 percent