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Compared to sgRNA controls, sg CBS significantly reduced intracellular cystathionine, cysteine, and GSH levels

This combination of lowered serum IGF-1 and increased GH secretion leads to increased insulin resistanceas in the systemic deletion but also developed glucose intolerance [129, 209]

Finally, it should be noted that fully understanding the impact of biological Alzheimer's disease on dementia prevalence will require biomarkers for other dementiacausing conditions: even if asymptomatic people with biological Alzheimer's disease do go on to develop dementia, the primary cause may not be Alzheimer's disease but another condition or a combination of Alzheimer's disease and other pathologies

doi: 10.1002/advs.202404064 45 MusumeciDRovielloGNMontesarchioD

Exenatide once weekly versus liraglutide once daily in patients with type 2 diabetes (DURATION-6): a randomised, open-label study