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It includes a 4-6 week loading phase (higher doses, typically twice weekly), followed by a 4-6 week maintenance phase (lower doses, typically once weekly), then a 4-8 week off period before considering another cycle

Price et al., Cell Metabolism )

In summary, current strategies in oncology shift towards the targeted treatment exploiting identification of crucial signaling pathways for metastatic spread of tumor cells

This matters for meniscus cells (fibrochondrocytes) that are damaged during a tear