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The implication of COX-2-PG system in gastric carcinogenesis is supported by numerous studies showing that the inhibition of COX-2 prevents the growth of GC xenografts in nude mice and that aspirin use, which inhibits both COX-1 and COX-2 activity decreases the risk of developing of some types of GC (91)

Tolerance to high temperature stress in plants is often associated with an increase in antioxidant enzyme activities 41

Mitochondrial-related gene expression profiles suggest an important role of PGC-1alpha in the compensatory mechanism of endemic dilated cardiomyopathy