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But for the POTS patients we treat, its often the most impactful single intervention in their toolkit the one that turns a horizontal day into a vertical one

Although astrocytes can utilize fatty acids as an alternative energy source, prolonged reliance on lipid oxidation results in oxidative stress and mitochondrial impairment, exacerbating neurodegeneration 82

Scientists found that in obese mice, MOTS-c treatment reversed diet-induced obesity and insulin resistance the mice shed weight and their blood sugar control improved

and, most importantly, we see the same senitization to 5FU with other CI inhibitors, such as IACS-010759, phenformin and carboxyamidotriazole, as we do with metformin

Clinical trials testing the drug on 300 obese patients in Australia once a day for 12 weeks tripled the weight loss compared to a placebo