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Cytokines are produced transiently and act as humoral regulators activating or deactivating cells and protecting tissues from damage [8]

In addition, an increase in skin surface pH due to reduced levels of natural moisturizing factor, as occurs in FLG-deficient epidermis, could facilitate bacterial colonization and inflammation

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Postnatal Care: After birth, babies affected by HDN may require treatments (such as phototherapy to manage jaundice), additional blood transfusions, and close monitoring of bilirubin levels to prevent kernicterus