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Human efficacy data are limited

Inhibition or down-regulation of GDH expression leads to a reduction in -KG production, which in turn affects the normal physiological activity of the tumour in a manner that reduces energy supply

1.12 Hashimotos thyroiditis and endogenous factors In addition to external exposures, inherent biological characteristicssuch as sex, hormonal changes, and physiological statesfurther shape the risk and clinical expression of HT

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Along with lifestyle modification and weight loss, several agents, including pioglitazone, semaglutide, and obeticholic acid, have shown promise in the therapy of NAFLD (7)

Lillo-Moya J, Rojas-Sol C, Muoz-Salamanca D, Panieri E, Saso L, Rodrigo R