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11 October 2022

Beneficial commensals generally promote immune tolerance and help reinforce the intestinal barrier, whereas an overgrowth of pathogenic bacteria or loss of key symbionts (dysbiosis) can provoke systemic inflammation [34]

To further validate the ferroptosis-mediated synthetic lethality of ARID1A and c-MET, we established another ARID1A-isogenic cell model derived from the RKO CRC cell line, which has a frameshift mutation in ARID1A [30]

however, choline comprises only about 13% of the weight of phosphatidylcholine (111)

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