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This is not an oversightit is by regulatory design
The use of small molecules that alter the levels of ROS such as -phenethyl isothiocyanate (PEITC), buthionine sulphoximine, curcumin, or 2-cyano-3,12-dioxooleana-1,9-diene-28-oic acid (CDDO) derivatives, has been suggested for the treatment of cancer by promoting ROS generation and GSH depletion in cancer cells (Schumacker, 2006
J Biol Chem 274:318915 Magi S, Piccirillo S, Amoroso S, Lariccia V (2019) Excitatory amino acid transporters (EAATs): glutamate transport and beyond
Due to the dysregulation of GLS in a variety of cancers, GLS inhibition has attracted attention
The cellular availability of Cys and bidirectional flux of cellular thiols across the plasmalemma may influence the interaction of the GST tag
Repeat courses can be run if a new injury occurs or symptoms recur after the initial course
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