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Macrophages exist in two primary "modes" or "polarizations": M1 Macrophages (The Demolition Crew): During the immediate aftermath of an injury, macrophages adopt the M1 state

For instance, Fan et al

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So is -amanitin, the toxin in death-cap mushrooms ( Amanita phalloides ) that can cause fatal liver and kidney failure, and so are the main toxins in bee and scorpion venom