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Essentially, methylmercury is thought to disrupt some of the cell signaling taking place when neurons are forming.[ref] The term Mad as a hatter referred to the neurological changes from long-term mercury exposure

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467,468,469 Yildiz et al

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They also showed that the addition of a P-glycoprotein inhibitor (verapamil) significantly reduced the LC 50 (the concentration that is lethal to 50% of the individuals exposed) values of ivermectin

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however, the characteristics of the tinnitus, presence of depression, and ratings of quality of life and overall health were unchanged

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PF is predominantly distributed in the liver, kidneys, and spleen, which are important target organs for its therapeutic effects in diabetes

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