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20.4% CagriSema Trial REDEFINE 2 (NEJM 2025) Duration 68 weeks Population T2D + BMI 27 (n=1,206) Mean Weight Loss 13.7% CagriSema vs 3.4% placebo

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Leydig cell aging (Zhang et al., 2020, Aging) FOXO4-DRI improved testosterone secretion and the testicular microenvironment in aged mice by clearing senescent Leydig cells