We obtained monoclinic (space group P2 1 ) and orthorhombic crystals (space group P2 1 2 1 2 1 ) of hTrxR1 C497S,U498C in complex with its substrate hTrx1 C35S,C73S
In contrast to synthetic agents designed to block individual molecular targets, natural products exhibit a systems-oriented mode of action that aligns more closely with the multifactorial pathophysiology of ischemic AKI
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