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PATHOPHYSIOLOGY In the SNc, the two hallmark histopathologic features of PD are depigmentation of dopamine-producing neurons (i.e., loss of SNc neurons) and presence of Lewy bodies (neuronal cytoplasmic filamentous aggregates composed of the presynaptic protein -synuclein) in the remaining SNc neurons

When that framework is missing, even the best-researched combination can underperform or create unnecessary frustration

Documentation and pre-order guidance are available when labs need additional planning context

This disorder is caused by genetic changes like mutations in the GSS gene

5B, C), although the Nrf2 gene was less efficiently deleted compared to the deletion of Gclc