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FIGURE 1 Transcriptional regulation of eNOS The NOS3 gene is located on chromosome 7 (7q35-36) and is regulated by a promoter region containing binding sites for multiple transcription factors, including Krppel-like Factor 2 (KLF2), Specificity protein 1 (Sp1), Specificity protein 3 (Sp3), Ets1, mothers against decapentaplegic homolog-2 (Smad2), and Nuclear factor erythroid 2-related factor (Nrf2), among others (Karantzoulis-Fegaras et al., 1999

Great experience overall

The manufacturer advises careful monitoring of liver function at the commencement of therapy and in the presence of any symptoms indicative of liver injury

And I think all of those are an issue

2 Chang CH, et al

Japan 7.4.3.1