[DOI] [PubMed] [Google Scholar] 447
1 Summary overview
This drug is unique because it can activate three different hormone receptors in the body that control appetite and metabolism
In the recent time, and by multivariable-adjusted analysis, factors such as female sex, diabetes, liver disease, proton pump inhibitors, abdominal pain, increased age, body mass index (BMI), and liver stiffness were associated with gallstone disease, while non-Hispanic Black and non-Hispanic Asian race and alcohol were inversely associated
In contrast, the detrimental effect of mitophagy mostly occurs in scenarios of excessive activation or abnormal regulation: when cells encounter sustained and severe pathological stress (such as severe ischemia and severe inflammation), mitophagy is abnormally activated, which excessively degrades functionally normal mitochondria, leading to disorders of cellular energy metabolism, insufficient ATP synthesis, and simultaneous disruption of the normal proliferation and renewal balance of mitochondria in cells
PMID: 31 TongJYaoGChenYXieHZhengXSunLet al