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Downmodulation of the NRF2 pathway was also confirmed by RT-qPCR analyses of four known NRF2 transcriptional targets ( GCLM , GSR , NQO1 , and MGST1 ) in both Hs 578T and MDA-MB-231 TNBC cells, showing reduced expression of these genes upon Cyss deprivation (Fig

Proc Natl Acad Sci USA 112:E5679E5688 Prasad S, Gupta SC, Tyagi AK (2017) Reactive oxygen species (ROS) and cancer: role of antioxidative nutraceuticals