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SW480 cells treated 5FU for 72 h analysed for mitochondrial mass by NAO staining ( a ) and mtDNA ( b ), n = 3 biological replicates shown with mean s.e.m in both, and mitochondrial protein expression ( c ), blots representative of n = 3 biological replicates

The real answer is both are effective, but together they work even better

Then, the peptide derivative NSBSO was obtained by classical solid-phase peptide synthesis using the above intermediates according to our previous literature [39, 40]

Abdelrazig S, Ortori CA, Doherty M, Valdes AM, Chapman V, Barrett DA

While in B16 cells with high GSH level, it indirectly increased the level of intracellular ROS by GSH depletion and activated Caspase 3 and then GSDME to induce pyroptosis

Be guided by your clinician as to the timing of retinols