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The total of four conversions of NAD + to NADH in the joint glutamate synthesis/oxidation process suggested [two in astrocytes during the production of -ketoglutarate and one during glutamate oxidation (Figure 3B), together with one in neurons (Figure 5)] may explain the close to 1:1 ratio between rates of glucose oxidation and of glutamine/glutamate (GABA) cycle flux

X-ray crystallographic studies have demonstrated that copper coordination occurs through the N-terminal amino group of glycine, the deprotonated peptide nitrogen of the Gly-His bond, and the imidazole nitrogen of histidine, forming a square-planar geometry characteristic of Cu(II) complexes

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10.3390/nu13093042 21 EdlingC

Moreover, intense exercise, as experienced by athletes and those committed to their physical craft, takes a biochemical toll as well