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Cytotoxicity of both QIs increased under GSH-depleted conditions, confirming that GSH is important as scavenger by GSH-conjugation and as endogenous antioxidant ( Figure 1 )

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Besides their enzymatic activity, cytosolic GSTs (such as class Alpha) exhibit an ability to bind various hydrophobic ligands (xenobiotics as well as hormones) and thus contribute to their intracellular transport and disposition

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Filler G, Amendt P, von Bredow MA, Rohde W, Ehrich JH (1998) Slowly deteriorating insulin secretion and C-peptide production characterizes diabetes mellitus in infantile cystinosis

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