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Well-designed randomized clinical studies are needed to systematically evaluate the evidence for the use of these hepatoprotective agents as treatment options for APAP-induced liver injury, to determine the timing of initiation of the therapy, and to further define the optimal treatment regimen

M.BogueM.DenzelM

271,272 Mutations of mtDNA which encodes respiratory chain proteins affect the respiratory chain stability and result in premature aging

doi: 10.3389/fimmu.2023.1121655 179 JiangYPWenJJZhaoXXGaoYCMaXSongSYet al

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Additionally, induced ERCs have been shown to differentiate into functional hepatocyte-like cells (Khademi et al., 2014)