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Injectable administration bypasses this limitation while topical application provides concentrated local delivery

When using them for cosmetic purposes, be sure to purchase a product made by a reputable company, and read the ingredients carefully

However, the lack of extensive human clinical trials means long-term safety data in humans remains limited

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Patients with these risk factors should discuss screening and supplementation strategies with their GP, particularly if experiencing symptoms such as fatigue, paraesthesia, glossitis, or cognitive changes suggestive of deficiency