NICE guidance distinguishes between dietary deficiency and deficiency caused by malabsorption conditions such as pernicious anaemia
Because B12 is water-soluble, excess is excreted by the body
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[20] For nutritional deficiency without intrinsic-factor loss, shorter courses-such as 30-100 mcg intramuscularly daily for five to ten days followed by 100-200 mcg monthly-are often sufficient