EBM Consult
Vitamin B12 Essentials 2.1 Biochemical Roles and Neurological Importance Vitamin B12 (cobalamin) is indispensable for two biochemical pathways: Methionine Synthase : Converts homocysteine to methionine, fueling methylation reactions vital for DNA synthesis, neurotransmitter production (serotonin, dopamine), and myelin maintenance
- Antihipertensive agents: NSAIDs may reduce hypotensive effects including ACE inhibitors
Who should consider getting B12 shots
MOTS-c (Mitochondrial-Derived Peptide) is a naturally occurring 16-amino acid peptide encoded by the mitochondrial genome (specifically the 12S rRNA gene)
Pathological causes of elevated B12 warrant careful consideration: Haematological disorders : Myeloproliferative neoplasms (polycythaemia vera, chronic myeloid leukaemia), acute leukaemia, and lymphoproliferative disorders can increase B12-binding proteins (transcobalamin and haptocorrin), elevating total serum B12 [3] Liver disease : Hepatocellular damage releases stored B12 into circulation
