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Because no official human dosing study exists

10.1002/advs.202502830 38 Hunault-BergerM.MaillardN.HimberlinC.RecherC.Schmidt-TanguyA.ChoufiB.et al (2017)

We further demonstrate that oxidative mitochondrial signalling can be used as a biomarker of response to fluoropyrimidine-based chemotherapy treatment in patients with CRC and may have clinical utility for stratifying patients at higher risk who could benefit from metabolically targeted combination therapies

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ROS injure cellular macromolecules e.g

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