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Recent preclinical studies and clinical trials show that TCM-derived metabolites can improve cardiovascular health
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doi: 10.1371/journal.pntd.0008540 [DOI] [PMC free article] [PubMed] [Google Scholar] 59
In cynomolgus monkeys, intra-ovarian injection of human embryonic stem cellderived MSC-like M cells reduced fibrosis and DNA damage, restored sex-steroid secretion, and supported the birth of a healthy infant, changes substantiated by single-cell RNA sequencing that showed dampened oxidative stress and inflammation in granulosa and stromal compartments [192]
Researchers identified that certain fragments of -MSH exhibited potent beneficial properties, even in isolation from the full hormone
The transcription factor Nrf2 is a potent transcriptional activator that plays a central role in the inducible expression of many cytoprotective genes in response to oxidative and electrophilic stresses ( Figure 1 )
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