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Nrf2 is the master regulator of antioxidant defense, and impaired Nrf2 activation leads to mitochondrial damage [123]

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Read review Dihexa for Sleep Apnea Brain Fog OSA & hypoxemia, REM CA1 hippocampal loss (UC Irvine May 2025), Zepbound (tirzepatide) FDA approval Dec 2024 (SURMOUNT-OSA), NICE NG202, and the ~13 million UK adults estimated to have OSA

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A trial that associated a low-carbohydrate diet with metformin and moderate exercise found that the patients who lost weight improved glucose metabolism and increased the incidence of natural pregnancy among obese females with PCOS [79]