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Results showed that the ingredient significantly increased NAD+ levels in senescent fibroblasts, activated the SIRT1 signaling pathway, reduced the expression of senescence-associated -galactosidase (SA--gal), decreased intracellular reactive oxygen species accumulation, and promoted collagen synthesis

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The intragastric administration route used in Sun 2021 reflects the BBB-permeability and oral-bioavailability profile characterized for Dihexa in the McCoy 2013 pharmacokinetic work