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Epoxides and other reactive intermediates formed from environmental procarcinogens mostly as a result of metabolism by cytochromes P450 (aflatoxin B 1 , polycyclic aromatic hydrocarbons, styrene, benzopyrene, heterocyclic amines) also undergo detoxification by soluble GSTs

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In plain language, it both removes old, damaged collagen and protects newly formed collagen

Li-Huei Tsais group found that cells carrying the variant run their phospholipid pathway poorly and extra choline reversed the defect, a low-risk and mechanism-based option for carriers even though the targeted human trials are not yet in

This prevents dilution and allows proper penetration