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Sandermann, 1992
Inhibition of the Xc-system determines the decrease in GSH levels, which indirectly leads to the inactivation of GPX4 and the onset of ferroptosis ( 3+ enters cells with the assistance of transferrin and subsequently converts to Fe 2+ ( 2+ can catalyze the generation of metabolically toxic reactive oxygen species and phospholipid peroxide through the Fenton reaction, leading to cell damage or death (Figure 4)
As a result, the livers ability to produce the master antioxidant, glutathione, is reduced leading to oxidative damage, fatigue, and premature aging
In particular, USP22 raised GSH content and reduced the occurrence of ferroptosis in cardiomyocytes by activating the Sirt1-p53/SLC7A11 axis [252]
10.1111/cpr.13485 102 ShenZ.DongW.ChenZ.ChenG.ZhangY.LiZ.et al (2022)
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